14-day Rome to Sicily road trip 

A Rome to Sicily road trip is one of the most fun, and jam-packed, adventures you can experience in Italy. 

It’s one that blends a rich tapestry of history with coastal scenery, diverse food cultures and different regions.  

In this Italy travel guide, I’ll be sharing my 14-day Rome to Sicily road trip itinerary. This southern Italy itinerary will take you from the historic streets of Rome to the sights of exhilarating Palermo. 

The guide will cover beautiful destinations to visit from Rome to Sicily as well as answer your frequently asked questions. 

Feel free to customize this itinerary as you wish; it’s merely a helpful guide to help plan your Italy trip. 

How to get from Rome to Sicily? 

There are many ways, and transport modes, to get from Rome to Sicily depending on your timeline and travel style. 

Whether you're driving the full route or combining segments with car and ferry, this 14-day itinerary covers plenty of ground. 

Flights from Rome to Sicily 

Flights from Rome to Sicily are the fastest and most convenient way to get from one destination to the other. Naturally, this excludes the option of doing a road trip.  

The flight time from Rome to Palermo or Catania is approximately 1hr 10mins. 

• Airports in Rome: Fiumicino (FCO) & Ciampino (CIA) 
• Airports in Sicily: Palermo (PMO), Catania (CTA), Trapani (TPS), Comiso (CIY), Pantelleria (PNL), Lampedusa (LMP) 
• Airlines: ITA Airways, Ryanair, easyJet, Volotea 

Best for: travelers with limited time who want to maximize their stay in Sicily. 
Tickets: prices will vary depending on the season. 

Train from Rome to Sicily 

There are direct trains from Rome Termini train station to Palermo and Catania in Sicily. 

The experience is unique as it consists of the train being loaded onto a ferry across the Strait of Messina. Search for tickets on Omio from Roma Termini train station to either Messina Centrale or Palermo Centrale. 

The average travel time from Rome to Palermo is around 11 to 12 hours. From Rome to Catania, this can take around 10 to 11 hours. 

Ticket prices can range from €80 ($87/£67) to €113 ($123/£95). However, this depends on the time of year, time of travel and class. 

Pros of taking the train 

✅ Scenic route, overnight options available. 

Cons 

❌ A long, and tiring, journey more so if traveling to Italy with a baby. 

Rome to Sicily by car and ferry 

Hiring a car gives you complete freedom to stop where you want and whenever you want. The ferry also adds a scenic addition to your Rome to Sicily road trip. 

Route 1 

Rome → Reggio Calabria → ferry to Messina → Sicily (via Villa San Giovanni)  
Drive: approximately 7.5 to 9 hours 
Ferry: around 25 minutes 

Route 2 

Rome → Civitavecchia → ferry to Palermo  
Ferry: approximately 15 hours (operated by Grandi Navi Veloci) 

14-day Rome to Sicily road trip itinerary 

Day 1: Rome 

Begin your road trip in the captivating capital of Rome, a historic center where every corner tells a story.  

With just one day in Rome to spare focus on seeing the main attractions.  

Start at the Colosseum. Walk in the footsteps of ancient gladiators and learn about the fascinating spectacles that were once hosted here. Consider getting Colosseum and Roman Forum skip-the-line tickets to save time waiting in long lines. 

Next door, wander through the Roman Forum, once the center of Roman public life. Filled with ancient temples, basilicas and crumbling arches, it’s a first-hand look into a bygone era.  

Walk towards the Baroque masterpiece that is the Trevi Fountain. Throw in one coin (for a return visit to Rome), two to find true love or three for both. Make the short walk to visit the famous Spanish Steps but don’t do anything that could incur a fine. 

As the afternoon sets in, head toward Piazza Navona, one of the city’s most atmospheric squares. Cap your day with an early evening visit to the Vatican Museums and the Sistine Chapel. Michelangelo’s famous ceiling fresco will leave you speechless. 

End the day with dinner in the charming neighborhood of Trastevere. Stroll past ivy-covered facades and walk down cobblestone alleys. Dine at a local trattoria and try local dishes like cacio e pepe followed by a glass of Lazio wine. 

If one day in Rome feels too short feel free to customize this Rome to Sicily road trip itinerary as you wish. 

Where to stay in Rome

💰 Budget – The Beehive  

A cozy and stylish hostel just a short walk from Roma Termini Station. Perfect for solo and/or budget-travelers looking for comfort and community. 

💰💰 Mid-range – Hotel Artemide  

Situated on Via Nazionale, this 4-star hotel combines modern comfort with historical elegance. Amenities include a rooftop restaurant and a spa. 

💰💰💰 Luxury – Rocco Forte Hotel de Russie  

A 5-star haven near Piazza del Popolo known for its romantic garden, impeccable service and elegant rooms. 

⏩️ Look for more hotels in Rome Italy

Day 2: Naples via Anagni and Caserta  

Depart Rome and start making the drive towards Naples. The drive takes around 3hrs or 141mi (227km). 

Arrival in Anagni

Approximately 1.5hrs from Rome is the enchanting town of Anagni. Known as the ‘City of Popes’ the town makes an interesting detour. 

Stroll through its narrow medieval streets to visit the Romanesque-Gothic Anagni Cathedral (Cattedrale di Anagni). Explore the cathedral’s crypt to see the 13th-century frescoes sometimes referred to as the ‘Sistine Chapel of the Middle Ages.’ 

Explore Caserta

Continue south towards Caserta, home to the spectacular Royal Palace of Caserta. 

Designed to rival Versailles, this 18th century UNESCO World Heritage site is unmissable (book skip-the-line tickets).  

Admire the grand halls with majestic chandeliers and frescoed ceilings and peek inside the royal apartments. Outside awaits manicured gardens with cascading fountains, mythological sculptures and a mile-long watercourse.  

A 50-minute drive (approximate) from Caserta takes you to the lively city of Naples.  

For dinner head to the no-frills, yet excellent L’Antica Pizzeria da Michele. As the birthplace of pizza, trying its famous food staple is a no brainer.  

L'Antica Pizzeria Da Michele, Via Cesare Sersale, 1 

Where to stay in Naples 

💰 Budget – Hostel of the Sun   

This centrally located hostel is a favorite among backpackers and budget travelers. It’s most known for its friendly vibe and free breakfast. 

💰💰 Mid-range – Hotel Piazza Bellini & Apartments 

Set in a restored 16th-century palace in the heart of the historic center. Rooms are large, modern and bright and come with all the mod cons for a comfortable stay. 

💰💰💰 Luxury – ROMEO Napoli 

A sleek, luxury 5-star hotel overlooking the bay of Naples. It has a rooftop pool, three restaurants and a full-service spa. 

⏩️ Look for more Naples Italy hotels

Day 3: Naples and Pompeii 

Spend the morning visiting some of the best attractions in Naples. Choose one or two top things to do in Naples in one day before visiting the ancient site of Pompeii.  

One such attraction is Underground Naples (Napoli Sotterranea – get advance entry tickets). As the name suggests, the site consists of a maze of tunnels, aqueducts and WWII shelters hidden beneath the city.  

Hit the road for the drive from Naples to Pompeii. The journey takes around 25 minutes (not factoring in traffic or other stops).  

Learning in Pompeii 

Get reserved entry tickets to see the city frozen in time by the eruption of Mount Vesuvius in 79 AD.

Walk along the ancient streets and peek inside well-preserved homes. Visit the Roman Forum and amphitheater to understand the complexity and advancement of Roman urban planning.  

Head back to Naples. Finish your evening with something sweet from La Sfogliatella di Mary situated inside the shopping center Galleria Umberto I.  

Walk off any excess calories by strolling along the waterfront promenade of Lungomare Caracciolo. 

La Sfogliatella di Mary, Galleria Umberto I, 66 

See above for Naples hotel recommendations. 

Day 4: The Amalfi Coast 

Day 4 of the Rome to Sicily road trip embarks on a visit to the Amalfi Coast. 

One of the most beautiful coastal drives in the world, be sure to get up early to avoid the traffic.  

You’ve several options to get from Naples to the Amalfi Coast. Each will differ in duration and route depending on which town you plan to visit.  

Sunning in Sorrento 

Sorrento is the closest (in distance) from Naples. Take the A3 motorway toward Sorrento then the SS145. Spend one day in Sorrento exploring the pretty town center and discovering its main sights. 

Hit the road once more in the direction of Positano and the SS163. This stretch of serpentine road clings to cliffs that plunge deep into the Tyrrhenian Sea. 

Pretty in Positano 

Positano is a social-media favorite town on the Amalfi Coast. Pastel buildings cascade down the hillside and the narrow alleys lead to the pebbled beach of Spiaggia Grande. 

Step inside its iconic cathedral and take photos of Positano town from the outside. For lunch, book a table with a Positano view at the picturesque Ristorante Don Giovanni.  

Amalfi and Ravello 

Pass the rest of the afternoon in the town of Amalfi. Approximately a 40-minute drive from Positano, Amalfi was once a powerful maritime republic.  

Visit the striking Amalfi Cathedral (Duomo di Amalfi), an Arab-Norman masterpiece, before exploring the shops in the town.  

If time permits, make the short drive up to see the town of Ravello. Perched high above the coast, Ravello is home to the enchanting Villa Rufolo and the 5-star hotel Villa Cimbrone. Both are known for their romantic gardens and sweeping sea views that have inspired poets and composers. 

As the sun begins to dip, choose between returning to Naples for the night — or staying overnight along the coast. 

Where to stay on the Amalfi Coast 

💰 Budget – Hotel Il Pino (Praiano)   

A charming 3-star hotel choice with a rooftop terrace and a free buffet breakfast.  

💰💰 Mid-range – Hotel Margherita (Praiano)  

A 4-star beach location hotel with seasonal outdoor pool, rooms with sea views and an onsite winery.  

💰💰💰 Luxury – Le Sirenuse (Positano) 

Experience one of the most iconic, and luxurious, hotels in Italy. Expect elegant and spacious rooms and suites with terraces, a champagne bar, outdoor dining and a spa. 

⏩️ Look for more Amalfi Coast hotels

Day 5: Positano to Cosenza 

Day 5 of the Rome to Sicily road trip consists of a longer drive further south. This leg of the itinerary starts from Positano and ends in the city of Cosenza in Calabria. 

The drive takes approximately 3hrs 34mins 198mi (318km) but it can take longer depending on road conditions on the day. 

As you drive through Campania and into Basilicata, watch the landscape transform into dramatic mountain ranges and sun-drenched valleys.  

Ciao Cosenza 

A city rich in history and off the radar for many tourists, Cosenza is the capital (capoluogo) of the Calabrian region. 

Begin your exploration of Cosenza in its historic center (centro storico). Weave through the labyrinth of narrow alleyways, staircases and piazzas until you reach Cosenza Cathedral (Cattedrale di Santa Maria Assunta).  

Cosenza Cathedral (Cattedrale di Santa Maria Assunta), Piazza Duomo, 1 

The UNESCO-listed Romanesque church houses masterpieces from different eras including 15th century frescoes. Wander past medieval buildings that sit alongside contemporary murals and sculptures.  

The Museo all’Aperto Bilotti (MAB) is a prime example in Cosenza. The open-air museum on Corso G. Mazzini lines the street with works by Salvador Dalí, Giorgio de Chirico and Mimmo Rotella.  

It’s a unique contrast to the city’s historic side and proof that Cosenza effortlessly blends the old with the avant-garde. 

Museo all’Aperto Bilotti (MAB), Corso G. Mazzini 

For dinner, book a table at Al Vicoletto. Sample Calabrian specialties like fileja pasta with ‘nduja or pork cooked with chili peppers and wild fennel. Enjoy with a glass of Calabrian Cirò Rosso wine. 

Al Vicoletto, Via Simonetta Francesco, Via Francesco Gioia, 9 

Where to stay in Cosenza 

💰 Budget – Hotel Excelsior  

The 3-star hotel is a 9-minute walk from Cosenza Cathedral. Some of the rooms come with a balcony and all come with a private bathroom with a bidet. 

💰💰 Mid-range – Hotel Europa  

A family-friendly 4-star hotel, the hotel has comfortable rooms, seasonal pool and is steps from the Metropolis Shopping Mall. 

💰💰💰 Luxury – Italiana Hotels Cosenza  

Located near Lake Arvo, this 4-star hotel has sleek and stylish rooms and an onsite gym and restaurant. A daily buffet breakfast is included and the hotel also welcomes furry companions. 

⏩️ Look for more Cosenza Italy hotels

Day 6: Cosenza to Reggio Calabria 

Continue the Rome to Sicily road trip south along the Tyrrhenian coastline, one of Italy’s most rugged coastal drives.  

The drive from Cosenza to Reggio Calabria takes around 1hr 50mins or 115mi (185km). 

Pause in Pizzo 

Consider stopping for a morning coffee or light lunch in Pizzo, a charming town in Vibo Valentia.  

The town’s famous for its decadent Tartufo di Pizzo dessert. The ball of chocolate and hazelnut gelato with a molten chocolate core is a must try when visiting. 

Several gelateria in Pizzo serve its namesake tartufo ice cream. Gelateria Morino Pizzo dal 1973, L’Angolo del Gelato and Tartufo di Pizzo GRANDINETTI are some notable places. 

• Gelateria Morino Pizzo dal 1973, Piazza della Repubblica, 13 
• L’Angolo del Gelato, Piazza Giuseppe Garibaldi, 1 
• Tartufo di Pizzo GRANDINETTI, Via Nazionale, VII° Traversa 

Pizzo’s other famous landmark is the 13th century Murat Castle (Castello Murat). It’s where Joachim Murat, Napoleon’s brother-in-law, met his dramatic end by firing squad in 1815. 

After visiting Pizzo continue driving south on the E45 for around another hour until you arrive in Reggio Calabria. 

Time permitting, consider making a short stop at the town of Scilla (on the way to Reggio). Located by the sea and famous for its sandy beach and swordfish sandwiches I’d recommend dropping by. 

Arrival in Reggio Calabria 

Reggio Calabria is Italy’s southernmost mainland city. The city has a gorgeous lakefront promenade (Lungomare Falcomatà) that overlooks the sparkling blues of the Tyrrhenian Sea. 

Sometimes referred to as ‘the most beautiful kilometer in Italy’ the promenade is close to beachfront restaurants, bars and art nouveau villas. With views across the Strait of Messina to Sicily it’s the perfect place to relax after a long drive. 

Get tickets to visit the National Archaeological Museum of Reggio Calabria (Museo Archeologico Nazionale di Reggio Calabria). It's home to the legendary Riace Bronzes — two life-size Greek statues dating from 460 to 450 BC.  

The masterpieces are among some of the most important classical sculptures ever discovered and worth the visit alone. 

National Archaeological Museum of Reggio Calabria (Museo Archeologico Nazionale di Reggio Calabria), Piazza Giuseppe De Nava, 26 

Where to stay in Reggio Calabria 

💰 Budget – Lungomare Hotel  

A basic but comfortable hotel located steps from the beach promenade. 

💰💰 Mid-range – Grand Hotel Excelsior  

Wake up to beach and sea views at this 4-star hotel. Look forward to comfortable rooms, a rooftop bar and a location that’s just minutes’ walk from the museum. 

💰💰💰 Luxury – èHotel 

This art deco hotel has stylish rooms overlooking the strait plus a rooftop bar and onsite restaurant. 

⏩️ Look for more Reggio Calabria hotels

Day 7: Messina and Taormina 

After 1 week on the road, the halfway point of the Rome to Sicily road trip finally arrives in Sicily. 
Upon departing Reggio Calabria, drive to Villa San Giovanni (around 20 minutes).  

As detailed in how to get from Calabria to Sicily by car, it’s where ferries shuttle vehicles across the Strait of Messina.  

The ferry ride is brief, about 25 minutes and the views are worth staying outside for.  

Quick tour in Messina 

Disembark in Messina, and time permitting, make a quick stop to see Messina Cathedral (Basilica Cattedrale "Santa Maria Assunta").  

Its astronomical clock is one of the largest and most intricate in the world. At noon each day the golden statues put on a brief but captivating show. 

On to Taormina 

The drive from Messina to Taormina takes around 40 minutes (not factoring in traffic). One thing I can say as someone who lives (part time) in Sicily, is that there’s usually road works somewhere. 

Because of this, allow sufficient time to get to your destination. 

Perched on a mountainside with sweeping views of the Ionian Sea Taormina has enchanted travelers for centuries.  

Most first-time visitors head straight to the Ancient Theatre of Taormina, a Greco-Roman amphitheater that remains in good condition.  

Book skip-the-line tickets to tour its tiered seating, from which you can enjoy panoramic views of Mount Etna. Slowly stroll through the main shopping street of Corso Umberto, lined with shops, bars and cafes leading to majestic piazzas. 

For dinner, book an outdoor table with a view at Ristorante Al Saraceno. The restaurant menu ranges from Sicilian seafood dishes to pizza.  

Ristorante Al Saraceno, Via Madonna della Rocca, 16 

Where to stay in Taormina 

💰 Budget – Casa Cuseni, UNESCO Intangible Cultural Heritage  

An artist’s house turned B&B, some rooms have terraces with sea views. Other amenities include an outdoor seasonal pool and complimentary breakfast. 

💰💰 Mid-range – Hotel Villa Schuler  

A gorgeous hotel with elegant rooms, garden terraces and walking distance to Corso Umberto and the Ancient Greek Theatre. 

💰💰💰 Luxury – Grand Hotel Timeo, A Belmond Hotel  

A timeless 5-star hotel with unmatched views, luxury service and an intimate terrace overlooking the sea and Mount Etna. 

⏩️ Look for more Taormina hotels

Day 8: Mount Etna and Catania 

While here, don’t miss the chance to visit a local Etna winery like Tenuta delle Terre Nere.  

Many use volcanic soil to produce some of Sicily’s most complex wines. Enjoy a tasting paired with local cheeses, cured meats and olives. 

Check out Catania 

After a morning excursion of Mount Etna make the approximate 1 hour trip to the historic center of Catania.  

A city built from black lava stone there’s a lot to see in one day in Catania. Start at Piazza del Duomo, where the Elephant Fountain (Fontana dell’Elefante) — carved from lava — guards Catania Cathedral (Basilica Cattedrale di Sant'Agata). 

Explore Via Etnea, Catania’s main shopping boulevard, or take a detour into the Roman Amphitheatre, partially hidden beneath modern buildings.  

For dinner, dive into a plate of Catania’s signature dish Pasta alla Norma. Made with fried eggplants, tomato sauce, ricotta salata and fresh basil it’s one of the best Sicilian dishes. 

Where to stay in Catania 

💰 Budget – The Yard Hostel  

Steps from Via Etnea this trendy and modern hostel has clean rooms, a terrace/patio area and an onsite bar. 

💰💰 Mid-range – Duomo Suites & Spa  

A family-friendly 4-star hotel with stylish rooms and suites in a central location. Other facilities include an onsite spa and rooftop terrace/patio. 

💰💰💰 Luxury – Romano House  

A sleek 4-star hotel blending Baroque architecture with contemporary style, close to all Via Etnea. 

⏩️ Look for more Catania hotels

Day 9: Syracuse and Ortigia 

Day 9 of the Rome to Sicily road trip starts with a visit to Syracuse (Siracusa). With origins tracing back to the 8th century BC, Syracuse is one of Sicily’s most ancient cities.  

Begin your Syracuse visit at the Neapolis Park (Parco Archeologico Neapolis), a vast archaeological park that includes the Greek Theatre.  

Visit the Ear of Dionysius, a towering limestone cave with unique acoustics. Sources say that it was used by tyrants to spy on prisoners. 

No list of what to see in Syracuse in 1 day would be complete without a visit to Ortigia island.  

Cross the bridge from Syracuse to visit attractions like Syracuse Cathedral (Cattedrale metropolitana della Natività di Maria Santissima). The cathedral, whose construction began in the 7th century, was built over a Greek temple.  

Syracuse Cathedral (Cattedrale metropolitana della Natività di Maria Santissima), Piazza Duomo, 5 

Visit Piazza Archimede, named after the city’s most famous son. Sit down to a sea view lunch at aLevante Restaurant and feast on some mouthwatering Sicilian seafood.  

aLevante Restaurant, Largo della Gancia, 5 

Spend the afternoon exploring sights like Castello Maniace, a fortress that guards the southern tip of Ortigia, and Arethusa Fountain.  

The antique fountain is one of the only places in Europe that grows papyrus. 

Map: Rome to Sicily road trip

Where to stay in Ortigia/Siracusa 

💰 Budget – Hotel Posta  

A 3-star pet-friendly hotel with clean, simple rooms and views of the harbor. 

💰💰 Mid-range – Palazzo Artemide – VRetreats   

A family-friendly hotel set in a Baroque building with elegantly furnished rooms and an onsite restaurant and bar. Steps away from Syracuse Cathedral. 

💰💰💰 Luxury – Algilà Ortigia Charme Hotel  

This romantic 4-star hotel perfectly blends antique decor with modern amenities. Facilities include two bars, a restaurant and bar. The lungomare di Ortigia (Ortigia lakefront promenade) is a 1-minute walk away.  

⏩️ Look for more Ortigia hotels

Day 10: Noto and Ragusa 

We start day 10 of this Rome to Sicily road trip itinerary with a visit to Sicily’s Val di Noto area.  

The region was reborn after the devastating 1693 earthquake that led to a unique and now UNESCO-listed Baroque architectural renaissance. 

Morning in Noto 

The drive from Syracuse to Noto is a short one, around 30 minutes or 23mi (37km).  

Sometimes referred to as the ‘capital of Sicilian Baroque’ there’s plenty of Sicilian architecture in Noto to see.  

Stroll down the honey-colored Corso Vittorio Emanuele, flanked by ornate churches and palazzi. It's home to some of the best things to do in Noto like visiting its majestic cathedral (Cattedrale di San Nicolò). With its dramatic staircase and reconstructed dome, it’s impossible to miss and one of the most beautiful churches in Sicily. 

Enjoy a mid-morning granita Siciliana with brioche at Caffè Sicilia. It’s a popular breakfast food in Sicily and this particular location was featured in Netflix’s TV series Chef’s Table. 

As someone who regularly visits Noto, I much prefer the granita and brioche at Bar Pasticceria Mangiafico.  

I’ve tried both places for their pastries and sweets and the selection, for me, is better at Bar Pasticceria Mangiafico. It’s also (usually) less busy than Caffè Sicilia. 

Caffè Sicilia, Corso Vittorio Emanuele, 125 
Bar Pasticceria Mangiafico, Via Ducezio, 2 

On to Ragusa 

From Noto, our Rome to Sicily road trip takes us to Ragusa Ibla. The drive takes around 40 to 50 minutes depending on road conditions on the day.  

The older section of Ragusa located in a deep gorge consists of a maze of cobblestone lanes, quiet piazzas and Baroque churches. 

Visit its principal cathedral, St. George’s Cathedral (Duomo di San Giorgio). Completed in 1775, the Baroque Catholic church houses notable sculptures and paintings.  

Stroll through the gardens at Giardino Ibleo and take in the views of the surrounding countryside. 

St. George’s Cathedral (Duomo di San Giorgio), Salita Duomo, 1 

Stop for lunch at one of the many excellent places to eat in Ragusa Ibla. Locanda Don Serafino is a boutique hotel inside a cave which has an excellent fine dining restaurant. 

Locanda Don Serafino, Via XI Febbraio, 15 

For something more rustic and down-to-earth, Quattro Gatti serves delicious food in a relaxed setting. 

Quattro Gatti, Via Valverde, 95 

Quick stop in Modica 

End the day with a short visit to Modica. Just 9mi (14km) from Ragusa Ibla, Modica is most famous for its unique chocolate-making tradition.  

Sample Aztec-style chocolate still made to ancient recipes at Antica Dolceria Bonajuto. Instead of adding milk they use spices like cinnamon or chili.  

Antica Dolceria Bonajuto, Corso Umberto I, 159 

Climb the grand steps to enter St. George’s Cathedral (Duomo di San Giorgio of Modica), one of Sicily’s most awe-inspiring churches. Explore the majestic interior before enjoying panoramic views over the tightly packed rooftops of the city. 

St. George’s Cathedral (Duomo di San Giorgio of Modica), Corso S. Giorgio 

Take a look at my Ragusa and Modica guide for a more detailed breakdown. 

Where to stay (Ragusa or Modica) 

💰 Budget – IBLA BAROCCA BNB  

Clean and bright rooms with free parking connected to the convention center in Ragusa. Breakfast available for a fee. 

💰💰 Mid-range – Epoca – Camere con stile  

This 3-star hotel has generous sized rooms, a rooftop terrace and is situated close to Giardino Ibleo.

💰💰💰 Luxury – Hotel Eremo della Giubiliana  

A luxurious 5-star countryside retreat situated in a converted monastery. Amenities include a spa, outdoor pool and a nearby private beach.  

⏩️ Look for more Ragusa or Modica hotels

Day 11: Ragusa to Agrigento 

Wake up early to depart Ragusa for Agrigento for day 11 of the Rome to Sicily road trip. 

The drive of approximately 87mi (140km) takes around 2hrs 20mins journeying from southern Sicily to the southwest. Though a long drive it’s a scenic one that passes through the fertile lands of south and southwestern Sicily. 

Arrival in Agrigento 

Most people come to Agrigento to see one thing: the Valley of the Temples (Valle dei Templi).  

One of the world’s most significant archaeological sites, it’s home to well-preserved Greek temples that date to the 5th century BC.  

Book skip-the-line tickets in advance for the Valley of the Temple to jump any long lines. 

Walk the long promenade through almond groves and cypress trees to explore the park’s vast grounds.

The Temple of Concordia, Temple of Juno and Temple of Heracles are considered some of the best-preserved Doric temples.  

Set against the backdrop of the sea makes the temples that more incredible to see in person. It's no wonder why the park is considered one of the best things to do in Sicily. 

See the Turkish Steps 

After a few hours exploring the archaeological park make the short drive to see the Turkish Steps (Scala dei Turchi). This striking white limestone cliff rises like a staircase from the turquoise sea. 

The natural steps — shaped by centuries of wind and water — are perfect for lounging or for enjoying the sea views. 

Time, and weather, permitting, go for a swim, or bathe, on the beach below.     

Back to Agrigento 

Before dinner, make a stop at Agrigento’s historic center. Wander through its narrow streets, stop by its baroque churches and take a pause in its pretty piazzas.  

Some noteworthy Agrigento restaurants to try include: 

• Cozzitorto Osteria del Capitano, Via Oblati, 28 
• Mabel il Ristorante da bere, Via Atenea, 223 
• Pizzeria Ristorante Still Life 2.0, Via Dante Alighieri, 109 

Where to stay in Agrigento 

💰 Budget – Il Meraviglioso Mondo di Amélie   

A welcoming and artsy B&B in Agrigento old town with personalized touches. 

💰💰 Mid-range – Hotel Della Valle 

A modern hotel close to the Valley of the Temples with gardens, full-service spa and a seasonal outdoor pool. 

💰💰💰 Luxury – Villa Athena Resort 

Wake up to views of the Temple of Concordia from your terrace at this 5-star luxury hotel. Located inside the archaeological park the pet-friendly resort also has an onsite spa and seasonal outdoor pool.

⏩️ Look for more Agrigento hotels 

Day 12: Trapani 

Leave Agrigento behind and follow the coastal road towards Trapani for day 12 of the Rome to Sicily road trip.  

Mid-morning in Marsala 

Approximately a 2-hour drive (approximate) from Agrigento takes you to the city of Marsala. 

Famous for its fortified wine production, booking a Marsala wine tasting is one of the most popular activities. 

Tour a historic cantina, such as Cantine Florio or Donnafugata, to sample sweet and dry Marsala wines.  

After the wine tasting, stroll through Marsala’s historic center to visit some of its main sights. Museo Archeologico Baglio Anselmi is a museum that houses a preserved Punic ship and artifacts from Marsala’s past. 

Museo Archeologico Lilibeo già Museo Archeologico Baglio Anselmi, Lungomare Boeo, 34 

If time allows, take in the sea views from the Lungolago Boeo. The lakefront promenade is a relaxing way to enjoy a different side of the city.  

From Marsala, drive north through the Saline dello Stagnone, a lagoon dotted with windmills and shimmering salt pans. Look out for flamingos pausing on the flat waters.  

Continue to see the processing plants and centuries old salt pan at Saline Ettore e Infersa. Join a guided tour to learn more about the sea salt production and harvesting process. 

Afternoon in Trapani 

Depart Marsala for the 38-minute drive towards Trapani. 

The historic port city is known for its windmills, coral jewelry and seafood. 

Spend the afternoon visiting the old town, admiring the baroque palaces and walking the length of the seafront promenade. 

Like Marsala, Trapani also has its own Trapani Salt Pans Nature Reserve (Riserva naturale orientata "Saline di Trapani e Paceco").  

Consider joining a guided tour of the Trapani salt pans to get an in-depth look into the salt production methods.  

End your day visiting Via Torrearsa. The main street in Trapani’s historic center has plenty of shops and bars guaranteed to keep visitors busy.  

Have dinner at nearby Ristorante arabo Carthage to sample Arab-influenced Sicilian dishes like couscous con pesce. 

Ristorante arabo Carthage, Via Nunzio Nasi, 8 

Where to stay in Trapani 

💰 Budget – CasaTrapani  

Large and bright rooms with modern decor and in-room dining in a central location. 

💰💰 Mid-range – Room of Andrea Hotel  

Stylish rooms in a beautifully restored palazzo just steps from Villa Regina Margherita. Other amenities include a rooftop bar, terrace/patio and a free daily buffet breakfast. 

💰💰💰 Luxury – Residence La Gancia  

Make your Trapani trip memorable with a stay at this waterfront 4-star hotel. Elegant and modern suites come with sea views and a rooftop terrace that was made for drinks at sunset. 

⏩️ Look for more Trapani hotels

Day 13: Erice and Castellammare del Golfo 

The penultimate day of the Rome to Sicily road trip takes us to Erice and Castellammare del Golfo. Should you prefer to spend more time in Palermo skip this section to day 14. 

Medieval morning in Erice 

It's a short drive (around 25 minutes) from Trapani to reach the medieval town of Erice.  

Surrounded by ancient walls and perched on a mountain overlooking the sea, visiting Erice feels like walking into a fairytale.  

Venus Castle (Castello di Venere) is a Norman castle built over a Roman temple. Wander the cobblestone streets, enjoy panoramic views from Piazza San Giovanni and try an almond cookie from Pasticceria Maria Grammatico. 

Pasticceria Maria Grammatico, Via Vittorio Emanuele, 14 

Lunch in Castellammare del Golfo 

From Erice it’s around a 45-minute drive to Castellammare del Golfo.  

The picturesque fishing village located between the mountains and sea makes the ideal spot for a seafood lunch. Dine at Ristorante La Cambusa to feast on fish dishes with a sea view.  

When done, walk down the pretty harbor to see the Arab-Norman castle (Castello Arabo-Normanno) overlooking the bay. Grab a gelato from a local gelateria and relax by the waterfront. 

In the late afternoon, drive the final stretch of the Rome to Sicily road trip to the Sicilian capital (capoluogo) of Palermo. It’s approximately a 1-hour drive from Castellammare del Golfo or 1hr 20mins from Trapani. 

Evening in Palermo 

Spend the evening exploring the shopping street of Via Vittorio Emanuele. It leads to one of Palermo’s most famous – and free – attractions, Quattro Canti.  

From here, walk to explore the historic Kalsa district — one of my top things to do in Palermo. The historic quarter is best known for its open-air markets and Moorish influences.  

Where to stay in Palermo 

💰 Budget – Hostel Agata 

Expect colorful and clean rooms with an onsite coffee shop/cafe. Pet-friendly and located near the Kalsa neighborhood. 

💰💰 Mid-range – Massimo Plaza Hotel  

Beautiful rooms directly facing the iconic Teatro Massimo in the center of Palermo at this 4-star hotel. Other facilities include an onsite cafe and bar. 

💰💰💰 Luxury – Grand Hotel Wagner  

A glamorous and historic 5-star hotel with opulent 19th century interiors. Prime location and one of the best breakfasts I’ve eaten in an Italian hotel.  

⏩️ Look for more Palermo hotels

Day 14: Palermo 

Spend your final day exploring more sights in Palermo, one of the most beautiful places in Sicily.  

Begin at Palermo Cathedral, a landmark that marries together Norman, Gothic and Baroque architectural styles.  

Move on to see the Norman Palace (Palazzo dei Normanni) and the dazzling Palatine Chapel (Cappella Palatina). The 12th century chapel with gold mosaics rival those that you find in Ravenna or Venice. 

Browse the goods at Ballarò and listen to vendors call out over the numerous food stalls. 

Take a breather in Teatro Massimo’s grand piazza or explore the modern art scene at Palazzo Riso.  

If time allows visit Monreale Cathedral, located just outside the city. Set eyes on the striking gold mosaics inside and the panoramic views outside. 

Celebrate your final evening of your Rome to Sicily road trip with dinner at Trattoria Ai Cascinari. Tuck into a classic Sicilian caponata and a meaty falsomagro main (if you eat meat). 

Stay at the same hotel of choice in Palermo as listed on day 13. 

Day 15: departure day 

Your two-week road trip from Rome to Sicily has come to an end.  

Make the drive back from Palermo to the airport; a trip that takes around 30 minutes. Allow sufficient time to drop off your rental car and to check in your bags before your flight. 

FAQs

How long does it take to drive from Rome to Sicily? 

Journey times can range from 7.5 to 10 hours to drive directly from Rome to Sicily. This will vary depending on the route you take, traffic, roadworks and stops.  

The ferry from Villa San Giovanni to Messina can add unexpected travel time due to boarding and crossing times. 

Is it better to fly or drive from Rome to Sicily? 

Given the subject of this guide, I’d say that it’s better to drive. But, if time is limited, flying is the fastest and most convenient option.  

Can you take a train from Rome to Sicily?
 

There are direct trains that travel from Rome to Sicily. The trains are ferried across the Strait of Messina to reach the island.  

How much does the ferry from Villa San Giovanni to Messina cost?
 

A roundtrip ticket for a car and two adults costs €69.30 ($76.4/£60).* 

Can you drive a rental car from mainland Italy into Sicily?
 

Most rental car companies allow travel into Sicily but confirm with your provider and ask about ferry insurance. 

Do I need an international driving permit (IDP) in Italy?
 

If you're from outside the EU, yes. Most non-EU travelers will need an IDP alongside their valid driver's license. 

What are your thoughts on this Rome to Sicily road trip itinerary? Does it look like a trip you’d like to do? Let me know your thoughts in the comments below. 

*information correct at the time of publishing.

Disclosure: This post may contain affiliate links, which means I may receive a commission if you click a link and purchase something that I’ve recommended. Thank you for your support.

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